2024
Alsaiari, S.K., Nadeef, S., Daristotle J.L., Rothwell, W., Du, B., Garcia, J., Zhang, L., Sarmadi, M., Forster, T., Menon, N., Lin, S.Q., Tostanoski, L.H., Hachmann, N., Wang, E.Y., Ventura, J.D., Barouch, D.H., Langer, R., Jaklenec, A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Science Advances 10, eadj6380(2024). DOI:10.1126/sciadv.adj6380.
Collins, J., Han, J., Sarmadi, M., Allison-Logan, S., vander Straeten, A., Perkinson C.F., Acolaste, S., Kanelli, M., Daristotle, J., Karchin, A., Henderson, M., Cruz, M., Artzi, D., Alsaiari, S.K., Zhang, L., Levy, L., Wood, L., Jing, L., McHugh, K.J., Bawendi, M.G., Langer, R., Jaklenec A. On-Patient Temporary Medical Record for Accurate, Time-Sensitive Information at the Point of Care. Advanced Functional Materials (2024).
2023
Eshaghi, B., Schudel, A., Sadeghi, I., Chen Z., Lee A.H., Kanelli M., Tierney F., Ingalls B., Francis D.M., Li G., Han J., von Andrian U., Langer R., Jaklenec A. The role of engineered materials in mucosal vaccination strategies. Nature Reviews Materials (2023).
Wang E. Y., Sarmadi M., Ying B., Jaklenec A., Langer R. Recent Advances in Micro- and Nano-scale Carrier Systems for Controlled Delivery of Vaccines. Biomaterials, 2023.
Li Z., Zhang S., Zuber F., Altenried S., Jaklenec A., Langer R., Ren Q. Topical application of Lactobacilli successfully eradicates Pseudomonas aeruginosa biofilms and promotes wound healing in chronic wounds. Microbes and Infection, 2023, p. 105176.
vander Straeten, A., Sarmadi, M., Daristotle, J.L., Kanelli M., Tostanoski L.H., Collins J., Pardeshi A., Han J., Varshney D., Eshaghi B., Garcia J., Forster T.A., Li G., Menon N., Pyon S.L., Zhang L., Jacob-Dolan C., Powers O.C., Hall K., Alsaiari S.K., Wolf M., Tibbitt M.W., Farra R., Barouch D.H., Langer R., Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nature Biotechnology (2023).
Featured by MIT News, Genetic Engineering & Biotechnology News (GEN), PGurus, Labratory Experience, NEWS.am, Health Thoroughfare, Newsmax Health, TechEBlog, Indian Education Diary, The Agenda, List23, The Good Men Project.
Kanelli M., Bardhan N.M., Sarmadi M., Alsaiari S., Rothwell W.T., Pardeshi A., De Fiesta D.C., Mak H., Spanoudaki V., Henning N., Han J., Belcher A.M., Langer R.S., Jaklenec A. A Machine Learning-optimized system for on demand, pulsatile, photo- and chemo-therapeutic treatment using near-infrared responsive MoS2-based microparticles in a breast cancer model. bioRxiv, 2023.04.16.536750.
2022
Di Z., Lu X., Zhao J., Jaklenec A., Zhao Y., Langer R., Li L. Mild Acidosis-Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers. Angewandte Chemie (International ed. in English), 61, e202205436, 2022.
Tang, W., Zhuang, J., Anselmo, A.c., Duan, A., Zhang, R., ..., Oxley, J., Daristotle, J., Collins, J., Langer, R., Jaklenec, A., 2022., Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification. PNAS. Vol 119, No. 51. e2211534119.
Sarmadi, M., Ta, C., VanLonkhuyzen, A., De Fiesta, D., Kanelli, M., Sadeghi, I., Behrens, A., Ingalls, B., Menon, N., Daristotle, J., Yu, J., Langer, R., Jaklenec, A., 2022., Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles. Science Advances. Vol 8, Issue 28.
Sadeghi, I., Lu, X., Sarmandi, M., Langer, R., and Jaklenec, A., 2022. Micromolding of Thermoplastic Polymers for Direct Fabrication of Discrete, Multilayered Microparticles. Small Methods. 2200232. , 222, 2200232
2021
Ding, Y., Li, Z., Jaklenec, A., and Hu, Q., 2021. Vaccine delivery systems toward lymph nodes. Advanced Drug Delivery Reviews, 179, p.113914.
Makvandi, P., Jamaledin, R., Chen, G., Baghbantaraghdari, Z., Zare, E.N., di Natale, C., Onesto, V., Vecchione, R., Lee, J., Tay, F.R., Netti, P., Mattoli, V., Jaklenec, A., Gu, Z., and Langer, R., 2021. Stimuli-responsive transdermal microneedle patches. Materials Today, 47, pp. 206-222.
2020
Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K.J, Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D.G., and Jaklenec, A., 2020. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Science Translational Medicine,12, eaaz6606.
Abstract. Full text.
Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H.T.M., Tochka, Z.L., Lu, X., Langer, R., Jaklenec, A., 2020. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6(28).
Langer, R., Jaklenec, A., Traverso, G. and Hartman, D., 2020. From molecule to patient: a biotech perspective. Clinical Pharmacology & Therapeutics, 107(1), pp.65-67.
Yeom, J., Guimaraes, P.P., Ahn, H.M., Jung, B.K., Hu, Q., McHugh, K., Mitchell, M.J., Yun, C.O., Langer, R. and Jaklenec, A., 2020. Chiral Supraparticles for Controllable Nanomedicine. Advanced Materials, 32(1), p.1903878.
Featured by MIT News, Science Daily, PhysOrg, EurekAlert! (AAAS).
2019
McHugh, K.J., Jing, L., Severt, S.Y., Cruz, M., Sarmadi, M., Jayawardena, H.S.N., Perkinson, C.F., Larusson, F., Rose, S., Tomasic, S., Graf, T., Tzeng, S.Y., Sugarman, J.L., Vlasic, D., Peters, M., Peterson, N., Wood, L., Tang, W., Yeom, J., Collins, J., Welkhoff, P.A., Karchin, A., Tse, M., Gao, M., Bawendi, M.G., Langer, R. and Jaklenec, A. 2019. Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination. Science Translational Medicine, 11(523).
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Anselmo, A.C., Xu, X., Buerkli, S., Zeng, Y., Tang, W., McHugh, K.J., Behrens, A.M., Rosenberg, E., Duan, A.R., Sugarman, J.L., Zhuang, J., Collins, J., Lu, X., Graf, T., Tzeng, S.Y., Rose, S., Acolatse, S., Nguyen, T.D., Le, X., Guerra, A.S., Freed, L.E., Weinstock, S.B., Sears, C.B., Nikolic, B., Wood, L., Welkhoff, P.A., Oxley, J.D., Moretti, D., Zimmermann, M.B., Langer, R., and Jaklenec, A. 2019. A heat-stable microparticle platform for oral micronutrient delivery. Science translational medicine, 11(518).
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C. C. Beh, S. Farah, R. Langer, and A. Jaklenec, in Antimicrobial Materials for Biomedical Applications, ed. A. J. Domb, K. R. Kunduru, and S. Farah, The Royal Society of Chemistry, 2019, ch. 12, pp. 325-347
2018
Li, Z., Behrens, A.M., Ginat, N., Tzeng, S.Y., Lu, X., Sivan, S., Langer, R. and Jaklenec, A., 2018. Biofilm‐Inspired Encapsulation of Probiotics for the Treatment of Complex Infections. Advanced Materials, 30(51), p.1803925.
Featured by MIT News, UPI, EurekAlert! (AAAS).
Glinel, K., Behrens, A., Langer, R.S., Jaklenec, A. and Jonas, A.M., 2018. Nanofibrillar Patches of Commensal Skin Bacteria. Biomacromolecules, 20(1), pp.102-108.
Tzeng, S.Y., McHugh, K.J., Behrens, A.M., Rose, S., Sugarman, J.L., Ferber, S., Langer, R. and Jaklenec, A., 2018. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. Proceedings of the National Academy of Sciences, 115(23), pp.E5269-E5278.
Featured by MIT News.
Ferber, S., Behrens, A.M., McHugh, K.J., Rosenberg, E.M., Linehan, A.R., Sugarman, J.L., Jayawardena, H.S.N., Langer, R. and Jaklenec, A., 2018. Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain. Advanced healthcare materials, 7(14), p.1800220.
Jonas, A.M., Glinel, K., Behrens, A., Anselmo, A.C., Langer, R.S. and Jaklenec, A., 2018. Controlling the Growth of Staphylococcus epidermidis by Layer-By-Layer Encapsulation. ACS applied materials & interfaces, 10(19), pp.16250-16259.
Kauffman, K.J., Oberli, M.A., Dorkin, J.R., Hurtado, J.E., Kaczmarek, J.C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A. and Anderson, D.G., 2018. Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP-flanked tdTomato reporter mouse. Molecular Therapy-Nucleic Acids, 10, pp.55-63.
McHugh, K.J., Jing, L., Behrens, A.M., Jayawardena, S., Tang, W., Gao, M., Langer, R. and Jaklenec, A., 2018. Biocompatible semiconductor quantum dots as cancer imaging agents. Advanced Materials, 30(18), p.1706356.
Guarecuco, R., Lu, J., McHugh, K.J., Norman, J.J., Thapa, L.S., Lydon, E., Langer, R. and Jaklenec, A., 2018. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Vaccine, 36(22), pp.3161-3168.
2017
McHugh, K.J., Nguyen, T.D., Linehan, A.R., Yang, D., Behrens, A.M., Rose, S., Tochka, Z.L., Tzeng, S.Y., Norman, J.J., Anselmo, A.C., Xu, X., Tomasic, S., Taylor, M.A., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A. 2017. Fabrication of fillable microparticles and other complex 3D microstructures. Science, 357(6356), pp.1138-1142.
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Schoellhammer, C.M., Lauwers, G.Y., Goettel, J.A., Oberli, M.A., Cleveland, C., Park, J.Y., Minahan, D., Chen, Y., Anderson, D.G., Jaklenec, A., Snapper, S.B., Langer, R. and Traverso, G., 2017. Ultrasound-mediated delivery of RNA to colonic mucosa of live mice. Gastroenterology, 152(5), pp.1151-1160.
Oberli, M.A., Reichmuth, A.M., Dorkin, J.R., Mitchell, M.J., Fenton, O.S., Jaklenec, A., Anderson, D.G., Langer, R. and Blankschtein, D., 2017. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano letters, 17(3), pp.1326-1335.
2016
Oberli M.A., Reichmuth A.M., Dorkin J.R., Mitchell M.J., Fenton O.S., Jaklenec A., Anderson D.G., Langer R., and Blankschtein D. 2016. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Letters, 2017 17 (3), 1326-1335.
Anselmo, A.C., McHugh, K.J., Webster, J., Langer, R. and Jaklenec, A., 2016. Layer‐by‐layer encapsulation of probiotics for delivery to the microbiome. Advanced Materials, 28(43), pp.9486-9490.
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Tzeng, S.Y., Guarecuco, R., McHugh, K.J., Rose, S., Rosenberg, E.M., Zeng, Y., Langer, R. and Jaklenec, A., 2016. Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release. Journal of Controlled Release, 233, pp.101-113.
Chen, X., Wu, B., Jayawardana, K.W., Hao, N., Jayawardena, H.S.N., Langer, R., Jaklenec, A. and Yan, M., 2016. Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria. Advanced healthcare materials, 5(16), pp.2007-2012.
Reichmuth, A.M., Oberli, M.A., Jaklenec, A., Langer, R. and Blankschtein, D., 2016. mRNA vaccine delivery using lipid nanoparticles. Therapeutic delivery, 7(5), pp.319-334.
Jaklenec, A., Anselmo, A.C., Hong, J., Vegas, A.J., Kozminsky, M., Langer, R., Hammond, P.T. and Anderson, D.G., 2016. High throughput layer-by-layer films for extracting film forming parameters and modulating film interactions with cells. ACS applied materials & interfaces, 8(3), pp.2255-2261.
2015
McHugh, K.J., Guarecuco, R., Langer, R. and Jaklenec, A., 2015. Single-injection vaccines: Progress, challenges, and opportunities. Journal of Controlled Release, 219, pp.596-609.
See Ana Jaklenec's publications on Google Scholar.