Publications from 2015 on


Alsaiari, S.K., Nadeef, S., Daristotle J.L., Rothwell, W., Du, B., Garcia, J., Zhang, L., Sarmadi, M., Forster, T., Menon, N., Lin, S.Q., Tostanoski, L.H., Hachmann, N., Wang, E.Y., Ventura, J.D., Barouch, D.H., Langer, R., Jaklenec, A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Science Advances 10, eadj6380(2024). DOI:10.1126/sciadv.adj6380.

Collins, J., Han, J., Sarmadi, M., Allison-Logan, S., vander Straeten, A., Perkinson C.F., Acolaste, S., Kanelli, M., Daristotle, J., Karchin, A., Henderson, M., Cruz, M., Artzi, D., Alsaiari, S.K., Zhang, L., Levy, L., Wood, L., Jing, L., McHugh, K.J., Bawendi, M.G., Langer, R., Jaklenec A. On-Patient Temporary Medical Record for Accurate, Time-Sensitive Information at the Point of CareAdvanced Functional Materials (2024).


Eshaghi, B., Schudel, A., Sadeghi, I., Chen Z., Lee A.H., Kanelli M., Tierney F., Ingalls B., Francis D.M., Li G., Han J., von Andrian U., Langer R., Jaklenec A. The role of engineered materials in mucosal vaccination strategies. Nature Reviews Materials (2023). 

Wang E. Y., Sarmadi M., Ying B., Jaklenec A., Langer R. Recent Advances in Micro- and Nano-scale Carrier Systems for Controlled Delivery of Vaccines. Biomaterials, 2023. 

Li Z., Zhang S., Zuber F., Altenried S., Jaklenec A., Langer R., Ren Q. Topical application of Lactobacilli successfully eradicates Pseudomonas aeruginosa biofilms and promotes wound healing in chronic woundsMicrobes and Infection, 2023, p. 105176.

vander Straeten, A., Sarmadi, M., Daristotle, J.L., Kanelli M., Tostanoski L.H., Collins J., Pardeshi A., Han J., Varshney D., Eshaghi B., Garcia J., Forster T.A., Li G., Menon N., Pyon S.L., Zhang L., Jacob-Dolan C., Powers O.C., Hall K., Alsaiari S.K., Wolf M., Tibbitt M.W., Farra R., Barouch D.H., Langer R., Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nature Biotechnology (2023). 
Featured by MIT News, Genetic Engineering & Biotechnology News (GEN), PGurus, Labratory Experience,, Health Thoroughfare, Newsmax Health, TechEBlog, Indian Education Diary, The Agenda, List23, The Good Men Project.

Kanelli M., Bardhan N.M., Sarmadi M., Alsaiari S., Rothwell W.T., Pardeshi A., De Fiesta D.C., Mak H., Spanoudaki V., Henning N., Han J., Belcher A.M., Langer R.S., Jaklenec A. A Machine Learning-optimized system for on demand, pulsatile, photo- and chemo-therapeutic treatment using near-infrared responsive MoS2-based microparticles in a breast cancer modelbioRxiv, 2023.04.16.536750. 


Di Z., Lu X., Zhao J., Jaklenec A., Zhao Y., Langer R., Li L. Mild Acidosis-Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers. Angewandte Chemie (International ed. in English), 61, e202205436, 2022.

Tang, W., Zhuang, J., Anselmo, A.c., Duan, A., Zhang, R., ..., Oxley, J., Daristotle, J., Collins, J., Langer, R., Jaklenec, A., 2022., Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification. PNAS. Vol 119, No. 51. e2211534119.

Sarmadi, M., Ta, C., VanLonkhuyzen, A., De Fiesta, D., Kanelli, M., Sadeghi, I., Behrens, A., Ingalls, B., Menon, N., Daristotle, J., Yu, J., Langer, R., Jaklenec, A., 2022., Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles. Science Advances. Vol 8, Issue 28.

Sadeghi, I., Lu, X., Sarmandi, M., Langer, R., and Jaklenec, A., 2022. Micromolding of Thermoplastic Polymers for Direct Fabrication of Discrete, Multilayered Microparticles. Small Methods. 2200232. , 222, 2200232


Ding, Y., Li, Z., Jaklenec, A., and Hu, Q., 2021. Vaccine delivery systems toward lymph nodesAdvanced Drug Delivery Reviews, 179, p.113914.

Makvandi, P., Jamaledin, R., Chen, G., Baghbantaraghdari, Z., Zare, E.N., di Natale, C., Onesto, V., Vecchione, R., Lee, J., Tay, F.R., Netti, P., Mattoli, V., Jaklenec, A., Gu, Z., and Langer, R., 2021. Stimuli-responsive transdermal microneedle patchesMaterials Today, 47, pp. 206-222.


Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K.J, Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D.G., and Jaklenec, A., 2020. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapyScience Translational Medicine,12, eaaz6606. 
Abstract. Full text.

Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H.T.M., Tochka, Z.L., Lu, X., Langer, R., Jaklenec, A., 2020. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6(28).

Langer, R., Jaklenec, A., Traverso, G. and Hartman, D., 2020. From molecule to patient: a biotech perspectiveClinical Pharmacology & Therapeutics, 107(1), pp.65-67.

Yeom, J., Guimaraes, P.P., Ahn, H.M., Jung, B.K., Hu, Q., McHugh, K., Mitchell, M.J., Yun, C.O., Langer, R. and Jaklenec, A., 2020. Chiral Supraparticles for Controllable Nanomedicine. Advanced Materials, 32(1), p.1903878. 
Featured by MIT News, Science DailyPhysOrg, EurekAlert! (AAAS).


McHugh, K.J., Jing, L., Severt, S.Y., Cruz, M., Sarmadi, M., Jayawardena, H.S.N., Perkinson, C.F., Larusson, F., Rose, S., Tomasic, S., Graf, T., Tzeng, S.Y., Sugarman, J.L., Vlasic, D., Peters, M., Peterson, N., Wood, L., Tang, W., Yeom, J., Collins, J., Welkhoff, P.A., Karchin, A., Tse, M., Gao, M., Bawendi, M.G., Langer, R. and Jaklenec, A. 2019. Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccinationScience Translational Medicine11(523). 
Featured by MIT News, Scientific American, Rice News, STAT, EurekAlert! (AAAS)Smithsonian, Optics & Photonics News, Health Day, Nature World News, South China Morning Post, Metro Newspaper UK, Jakarta Post and others.

Anselmo, A.C., Xu, X., Buerkli, S., Zeng, Y., Tang, W., McHugh, K.J., Behrens, A.M., Rosenberg, E., Duan, A.R., Sugarman, J.L., Zhuang, J., Collins, J., Lu, X., Graf, T., Tzeng, S.Y., Rose, S., Acolatse, S., Nguyen, T.D., Le, X., Guerra, A.S., Freed, L.E., Weinstock, S.B., Sears, C.B., Nikolic, B., Wood, L., Welkhoff, P.A., Oxley, J.D., Moretti, D., Zimmermann, M.B., Langer, R., and Jaklenec, A. 2019. A heat-stable microparticle platform for oral micronutrient deliveryScience translational medicine11(518). 
Featured by MIT News, NPR, New Scientist, Science DailyChemical & Engineering News, EurekAlert! (AAAS)Inverse, European Pharmaceutical Review, The Naked Scientist and others.

C. C. Beh, S. Farah, R. Langer, and A. Jaklenec, in Antimicrobial Materials for Biomedical Applications, ed. A. J. Domb, K. R. Kunduru, and S. Farah, The Royal Society of Chemistry, 2019, ch. 12, pp. 325-347



Li, Z., Behrens, A.M., Ginat, N., Tzeng, S.Y., Lu, X., Sivan, S., Langer, R. and Jaklenec, A., 2018. Biofilm‐Inspired Encapsulation of Probiotics for the Treatment of Complex Infections. Advanced Materials30(51), p.1803925. 
Featured by MIT News, UPIEurekAlert! (AAAS).

Glinel, K., Behrens, A., Langer, R.S., Jaklenec, A. and Jonas, A.M., 2018. Nanofibrillar Patches of Commensal Skin BacteriaBiomacromolecules20(1), pp.102-108.

Tzeng, S.Y., McHugh, K.J., Behrens, A.M., Rose, S., Sugarman, J.L., Ferber, S., Langer, R. and Jaklenec, A., 2018. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune responseProceedings of the National Academy of Sciences115(23), pp.E5269-E5278. 
Featured by MIT News.

Ferber, S., Behrens, A.M., McHugh, K.J., Rosenberg, E.M., Linehan, A.R., Sugarman, J.L., Jayawardena, H.S.N., Langer, R. and Jaklenec, A., 2018. Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold ChainAdvanced healthcare materials7(14), p.1800220.

Jonas, A.M., Glinel, K., Behrens, A., Anselmo, A.C., Langer, R.S. and Jaklenec, A., 2018. Controlling the Growth of Staphylococcus epidermidis by Layer-By-Layer EncapsulationACS applied materials & interfaces10(19), pp.16250-16259.

Kauffman, K.J., Oberli, M.A., Dorkin, J.R., Hurtado, J.E., Kaczmarek, J.C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A. and Anderson, D.G., 2018. Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP-flanked tdTomato reporter mouseMolecular Therapy-Nucleic Acids10, pp.55-63.

McHugh, K.J., Jing, L., Behrens, A.M., Jayawardena, S., Tang, W., Gao, M., Langer, R. and Jaklenec, A., 2018. Biocompatible semiconductor quantum dots as cancer imaging agentsAdvanced Materials30(18), p.1706356.

Guarecuco, R., Lu, J., McHugh, K.J., Norman, J.J., Thapa, L.S., Lydon, E., Langer, R. and Jaklenec, A., 2018. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccinationVaccine36(22), pp.3161-3168.


McHugh, K.J., Nguyen, T.D., Linehan, A.R., Yang, D., Behrens, A.M., Rose, S., Tochka, Z.L., Tzeng, S.Y., Norman, J.J., Anselmo, A.C., Xu, X., Tomasic, S., Taylor, M.A., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A. 2017. Fabrication of fillable microparticles and other complex 3D microstructuresScience357(6356), pp.1138-1142. 
Featured by BBC News, The Guardian, The Daily Mail, The Independent, Boston Magazine, O TempoNew Scientist, MIT News, NHS UK, The OnionChemical & Engineering News,, Engadget, EurekAlert! (AAAS), Yahoo! NewsFox News, 3Dprint, CBS Radio & TV, C&EN, Radio Sputnik and others.

Schoellhammer, C.M., Lauwers, G.Y., Goettel, J.A., Oberli, M.A., Cleveland, C., Park, J.Y., Minahan, D., Chen, Y., Anderson, D.G., Jaklenec, A., Snapper, S.B., Langer, R. and Traverso, G., 2017. Ultrasound-mediated delivery of RNA to colonic mucosa of live miceGastroenterology152(5), pp.1151-1160.

Oberli, M.A., Reichmuth, A.M., Dorkin, J.R., Mitchell, M.J., Fenton, O.S., Jaklenec, A., Anderson, D.G., Langer, R. and Blankschtein, D., 2017. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapyNano letters17(3), pp.1326-1335.


Oberli M.A., Reichmuth A.M., Dorkin J.R., Mitchell M.J., Fenton O.S., Jaklenec A., Anderson D.G., Langer R., and Blankschtein D. 2016. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer ImmunotherapyNano Letters, 2017 17 (3), 1326-1335.

Anselmo, A.C., McHugh, K.J., Webster, J., Langer, R. and Jaklenec, A., 2016. Layer‐by‐layer encapsulation of probiotics for delivery to the microbiome. Advanced Materials28(43), pp.9486-9490.
Featured by MIT News, Phys.orgPopular Science.

Tzeng, S.Y., Guarecuco, R., McHugh, K.J., Rose, S., Rosenberg, E.M., Zeng, Y., Langer, R. and Jaklenec, A., 2016. Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release. Journal of Controlled Release233, pp.101-113.

Chen, X., Wu, B., Jayawardana, K.W., Hao, N., Jayawardena, H.S.N., Langer, R., Jaklenec, A. and Yan, M., 2016. Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria. Advanced healthcare materials5(16), pp.2007-2012.

Reichmuth, A.M., Oberli, M.A., Jaklenec, A., Langer, R. and Blankschtein, D., 2016. mRNA vaccine delivery using lipid nanoparticlesTherapeutic delivery7(5), pp.319-334.

Jaklenec, A., Anselmo, A.C., Hong, J., Vegas, A.J., Kozminsky, M., Langer, R., Hammond, P.T. and Anderson, D.G., 2016. High throughput layer-by-layer films for extracting film forming parameters and modulating film interactions with cellsACS applied materials & interfaces8(3), pp.2255-2261.


McHugh, K.J., Guarecuco, R., Langer, R. and Jaklenec, A., 2015. Single-injection vaccines: Progress, challenges, and opportunitiesJournal of Controlled Release219, pp.596-609.

See Ana Jaklenec's publications on Google Scholar.